The main objective of BIOTOOL-CHF is to improve the efficiency, through personalization, of diuretic therapy for patients with heart failure with reduced ejection fraction with the aid of a decision-making tool integrating the diagnostic and prognostic information of a selected array of biomarkers with the clinical and demographic characteristics of each patient.

BIOTOOL-CHF research activities will lead to identification of a selected pool of biomarkers validated for prediction of fluid overload to be implemented in a companion diagnostic prototype. This tool coupled with a fluid retention score and a prognostic score integrated with a set of specific patient characteristics will be the basis to develop the BIOTOOL CHF Decision-Making Tool functional to help health care providers in managing fluid balance.

The project is constructed around six Specific Objectives